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Archive > Volume 24 Issue 3 > 2017,24(3):290-294. DOI:10.3872/j.issn.1007-385X.2017.03.013 Prev Next
Clinical Research
Expression of AFAP1-AS1 which belongs to lncRNA in gastric carcinoma tissues and its clinical significance
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Abstract:
Objective:To explore expression of actin filament-associated protein 1-antisense RNA1 (AFAP1-AS1), long non-coding RNA (lncRNA), in the gastric carcinoma tissues and its clinical significance. Methods: Using real-time PCR assay, expressions of AFAP1-AS1 in 274 cases of gastric carcinoma tissues and their corresponding adjacent normal gastric tissues which collected from the patients with gastric carcinoma who were hospitalized in the 2nd People Hospital of Yichang City and Renhe Hospital of Sanxia University for operative treatment during January 2010 to December 2014 were detected. And relationship between the expression of AFAP1-AS1 and clinicopathological features of the patients with gastric carcinoma was analyzed. Results: Expression of AFAP1-AS1 in the gastric carcinoma tissue was obviously higher than that in the adjaceut normal gastric tissues. Mean expression amount of AFAP1-AS1 in the early gastric carcinoma tissue was significantly lower than that in the advanced gastric carcinoma tissue (P<0.01). Among the gastric carcinoma tissues of various pathological types, expression amounts of AFAP1-AS1 were not significantly different (P>0.05). Expression amounts of AFAP1-AS1 were closely correlated with lymphatic invasion and distant metastasis of the gastric carcinoma. Expression amounts of AFAP1-AS1 in the gastric carcinoma tissue with local invasion and distant metastasis were obviously higher than those in the gastric carcinoma tissues without local invasion and distant metastasis (P<0.05). Conclusion:AFAP1-AS1 could be an important regulatory factor in the gastric carcinogenesis and development. It could be expected to become a novel marker for judging prognosis of the gastric carcinoma and used for clinical diagnosis and prognosis evaluation of the gastric carcinoma.
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