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Archive > Volume 24 Issue 3 > 2017,24(3):295-299. DOI:10.3872/j.issn.1007-385X.2017.03.014 Prev Next
Clinical Research
Expression of OTUD1 in NSCLC and its clinical significance
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Abstract:
Objective:To detect expression level of ovarian tumor domain-containing protease 1 (OTUD1) in the tissue of non-small cell lung cancer (NSCLC) and to explore relationship between the expression of OTUD1 and clinical pathological features and prognosis of the patients with NSCLC. Methods: Cancer tissues from 82 patients with NSCLC, who were hospitalized in Department of Thoracic Surgery, Qilu Hospital of Shandong University during March 2008 to February 2009 for operative treatment and 40 specimens of normal lung tissues were selected, and expression levels of OTUD1 were detected by immune histochemical method. And another 25 patients with primary NSCLC who were hospitalized in Department of Thoracic Surgery, Qilu Hospital of Shandong University during March to April 2015 for operative treatment were collected and expressions of OTUD1in the NSCLC tissues and their adjacent normal lung tissues were examined by Real-time PCR assay. Results: Comparing with the normal lung tissues, expressions of OTUD1 mRNA in NSCLC tissues were distinct higher （0.620±0055 vs 0.387±0.037, P<0.01）. Expression of OTUD1 did not significantly correlated with age, gender, smoking history and pathologic type of the patients with NSCLC (all P>0.05), and significantly correlated with lymph node metastasis, differentiation grads and TNM staging of the patiewts with NSCLC (P<0.05 or P<0.01). Results of univariate and multivariate analysis showed that high expression of OTUD1 associated with poor prognosis of the patients. Conclusion: High expression of OTUD1 in the NSCLC tissues could be closely related to malignant progression and poor prognosis of NSCLC. Expression of OTUD1 could be as a reference index to evaluate biological features of NSCLC and prognosis of the patients with NSCLC.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No.30571844), the Natural Science Foundation of Shandong Province (No.ZR2013HM089), and the Wu Jie Ping Medical Foundation (No.320.6750.12393)
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