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Archive > Volume 24 Issue 4 > 2017,24(4):335-340. DOI:10.3872/j.issn.1007-385X.2017.04.001 Prev Next
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Regulation mechanism of PD-L1 expression and its effect on antitumor immune responses
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Abstract:
Tumorigenesis is a complex process involving multistep. Tumor cells escape from immune of the host and promote their proliferation via inhibiting antitumor immune responses of the host. Molecular mechanism of the tumor immune escape is one of core issues about the tumor immune research. Programmed death receptor-1 (PD-1) is a key checkpoint for the inhibit immunity. The tumors can enhance inhibit signal of PD-1 and promote their immune escape through expression of programmed death ligand-1 (PD-L1). Research on how tumor cells regulate expression of PD-L1 can help to expound molecular mechanism of the tumor immune escape. Recently, some researches found tumor cells regulate expression of PD-L1 on multisteps of gene translation, post-transcriptional regulation and post-translational modification of proteins, as well as affect the anti-tumor immune responses through regulating expression of PD-L1. The researches provided novel targets for the immunotherapy of tumors.
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Project Supported:
Project supported by the National Key Research and Development Program of China (No.2016YFA0502201)
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