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Archive > Volume 24 Issue 4 > 2017,24(4):341-347. DOI:10.3872/j.issn.1007-385X.2017.04.002 Prev Next
Monographic Report
Progresses of research on detection of circulating tumor cells: from simple counting to analysis of phenotypes and function
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Abstract:
With development of novel techniques for targeted therapy, immunotherapy and so on, the tumor diagnosis and treatment have entered a new era of precision treatment. Liquid biopsy played an increasingly important role in the precision treatment of tumors as a convenient and noninvasive assay which could dynamically reflect the whole pictures of tumor gene spectrum. Detection of circulation tumor cells (CTCs) in blood is the earliest liquid biopsy technique and has been widely used in the early diagnosis, prognosis judgment, efficacy evaluation and so on for tumors. At primary stage, the detection of CTCs mainly based on a purely counting. However, a fact that the purely counting cannot really reflect the situations of tumor load and changes was gradually found. With continuous developments of sequencing technique and so on for a single cell, understanding of CTCs is also deepening and the detection of CTCs gradually turned to the advanced stage that is based on analysis of molecular phenotype and function. This paper mainly elaborated a development of CTCs detection from a primary stage to an advanced one and progresses of the research on its application in the precision treatment of tumor, combining with clinical practice for recent years.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81672350, No.81472770, No.81272280), and the Key Developing Discipline of Shanghai (No.2015ZB0202)
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