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Archive > Volume 24 Issue 5 > 2017,24(5):461-466. DOI:10.3872/j.issn.1007-385X.2017.05.001 Prev Next
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The design strategies for improving the efficacy and safety of CAR-T cells
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Abstract:
hard to reach the tumor positions and to improve their immunosuppressive microenvironment. When the CAR-T cells eliminate tumor cells, at the same time they also kill normal cells with the same target points. Efficacy of the CAR-T cells therapy for hematologic tumors and solid tumors except B cell tumors still needs to be improved. This paper focuses on that how the CAR-T cells could accurately identify tumor cells via optimization of the CAR-T cell structures and that effectiveness of the CAR-T cell therapy for malignant tumors could be enhanced through overcoming immunosuppressive microenvironment of tumors. At the same time, the CAR-T cells could be better controlled and safety of the CAR-T cells higher.
Keywords:
Project Supported:
Project supported by the Application Research and Achievement Promotion of Clinical Characteristics in the Capital City（No. Z161100000516184）
Clc Number:
