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Archive > Volume 24 Issue 5 > 2017,24(5):538-543. DOI:10.3872/j.issn.1007-385X.2017.05.014 Prev Next
Clinical Research
Expression level of miR-200c in gastric cancer and its relationship with clinical characteristics of gastric cancer patients
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Abstract:
Objective:To investigate the relationship between miR-200c expression and the clinical pathologic characteristics and disease free survival (DFS) of gastric cancer patients. Methods: Sixty-four gastric cancer samples resected from May 2012 to January 2016 at General Surgery Department of the Fourth Hospital of Hebei Medical University were collected in this study, and the relative clinical data were retrospectively analyzed. Real-time fluorescence quantification PCR was adopted to detect the expression of miR-200c in the gastric cancer tissues and corresponding para-cancerous tissues. The correlation between miR-200c expression and clinicopathological features as well as DFS was retrospectively analyzed. Results: miR-200c was dramatically decreased in gastric cancer tissues when compared to the para-cancerous tissues (329 vs 5.91, P<0.01). miR-200c expression was negatively correlated with TNM stage, tumor infiltration depth (T), metastasis(M), venous tumor thrombus (; all P<0.01). The median DFS in high miR-200c expression group was significantly longer than that of low expression group (22.0 vs 13.5 months, P<0.01), indicating a positive correlation between miR-200c expression and DFS (r=0.54, P<0.01). Conclusion:miR-200c dramatically decreased in gastric cancer tissues. Its expression level was negatively correlated with TNM stage, tumor infiltration depth and venous tumor thrombus, but positively correlated with DFS. These data suggest it may play a protective role in progress and prognosis of gastric cancer.
Keywords:
Project Supported:
Project supported by the Medical Science Research Emphasis of Health Department of Hebei Province（No.20170150）
Clc Number:
