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Archive > Volume 24 Issue 6 > 2017,24(6):632-639. DOI:10.3872/j.issn.1007-385X.2017.06.010 Prev Next
Clinical Research
Expressions of the melanoma antigenA family member in nonsmall cell carcinoma tissues and its significance
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Abstract:
Objective:To investigate the expression of melanoma antigen (MAGE)As in nonsmall cell carcinoma (NSCLC), and to explore its correlation with clinical pathological indicators and the prognosis. Methods: NSCLC tissue samples (n=90) and paracarcinoma tissue samples (n=90) were collected from 90 patients with NSCLC who were surgically treated in Fourth Hospital of Hebei Medical University between September of 2005 and March of 2006. The expression of MAGEAs protein in the 90 paired tissues was detected by immunohistochemistry assay, and its correlation to NSCLC clinical pathological indicators was analyzed. In addition, EGFR amplification and ALK rearrangements of NSCLC patients were detected by fluorescent in situ hybridization, and the association between MAGEAs expression and EGFR amplification and ALK rearrangements was analyzed with Spearman correlation analysis. The survival of NSCLC patients with positive MAGEAs expression was analyzed by KaplanMeier method. Cox regression model was used for univariate analysis and multivariate analysis of correlations between positive expression of MAGEAs and clinical pathological indicators. Results: The positive rates of MAGEAs protein in NSCLC were significantly higher than that of noncancerous tissues (P<0.05). MAGEAs expression was not correlated with clinical pathological indicators of NSCLC patients, EGFR amplification and ALK rearrangements(P>0.05). Logrank test showed that the survival time of NSCLC patients with positive MAGEAs expression were lower than those with negative expression (P<0.05); However, EGFR amplification and ALK rearrangements were not associated with the overall survival of NSCLC patients. Results from multivariate analyses showed that the expression of MAGEAs, clinical stage, lymph node metastasis were independent risk factors of NSCLC. Conclusion: MAGEAs proteins are NSCLCassociated antigens, thus having potential diagnostic and prognostic significance in clinical settings.
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Project Supported:
Project supported by the Financial Supporting Program of Hebei Province(No. 20141257) ， the Foundation for Distinguished Young Scholars of Hebei Province (No. H2016206410)， and the Financial Department of Hebei Province (No. 2016361006)
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