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Archive > Volume 24 Issue 6 > 2017,24(6):645-649. DOI:10.3872/j.issn.1007-385X.2017.06.012 Prev Next
Clinical Research
Expression of lncRNA AC007009.1 in tissues of nonsmall cell lung cancer and its clinical significance
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Abstract:
Objective:To investigate the expression and clinical significance of lncRNA AC007009.1 in tissue samples of nonsmall cell lung cancer (NSCLC). Methods: The expression of lncRNA AC007009.1 in 105 NSCLC tissue samples, 72 adjacent normal tissue samples and 33 normal tissue samples was detected by qRTPCR method; and the relationship between lncRNA AC007009.1 expression and clinical pathological characteristics of NSCLC was analyzed; in addition, the correlation between lncRNAAC007009.1 expression and the OS and PFS of NSCLC patients was also analyzed. Results: Expression of lncRNAAC007009.1 was significantly increased in tumor tissues than that in noncancerous tissues (5.30±1.96 vs 1.01±0.33, 0.99±0.29，P<0.01). AC007009.1 expression was positively correlated with disease stage，distant metastasis，pathological type and survival status (P<0.05); Moreover, the OS and PFS of patients with high lncRNAAC007009.1 expression were significantly shorter than the patients with low expression (P<0.01). Cox multivariate analysis also indicated that lncRNAAC007009.1 expression, disease stage, distant metastasis were the independent prognostic markers for NSCLC (all P<0.05). Conclusion: LncRNA AC007009.1 is involved in the development of NSCLC, and can be used as a molecular marker for the diagnosis and prognosis of nonsmall cell lung cancer.
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Project Supported:
Project supported by the National Natural Science Foundation of China（No.81301910)
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