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Archive > Volume 24 Issue 6 > 2017,24(6):650-655. DOI:10.3872/j.issn.1007-385X.2017.06.013 Prev Next

Clinical Research

Expressions and clinical significance of 21 cytokines in the serum of patients with lung cancer

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    Abstract:
    Objective:To detect the expressions of 21 cytokines (ITAC\[IFNinducible T cell α chemoattractant\], GMCSF, Fractalkine, IFNγ, L10, MIP3α \[macrophage inflammatory protein3α\], IL12(p70), IL13, IL17A, IL1β, IL2, IL4, IL21, IL23, IL5, IL6, IL7, IL8, MIP1α, MIP1β and TNFα) in serum of patients with lung cancer, and analyze their clinical significance. Methods: Thirty healthy controls and forty newly diagnosed patients with lung cancer before treatment were enrolled for the detection of serum levels of 21 cytokines by liquid chip. The correlations between clinical characteristics of lung cancer and these cytokines were analyzed; in addition, the correlations between significantly differentiallyexpressed cytokines were also analyzed.Results: The expressions of 11 cytokines, including GMCSF, IFNγ, IL12(P70), IL1β, IL2, IL6, IL7, TNFα, Fractalkine, IL8, and MIP3α(P<0.05 or P<0.01) in serum of patients with lung cancer were significantly higher than those in control group. However, there was no significant difference in the serum levels of 21 cytokines between nonmetastasis group and metastasis group of lung cancer patients. The serum expressions of IFNγ(P<0.05) and MIP1β(P<0.05) in lung adenocarcinoma (AC) patients were significantly higher than that in squamous cell carcinoma (SCC) patients. And the expression of ITAC (P<005) in SCC group was significantly higher than that in small cell lung carcinoma group (SCLC group). The 11 highly expressed cytokines showed different correlations in two groups. Conclusion: The expressions of 11 cytokines were significantly increased in patients with lung cancer, including IL6 and IL8 etc. It suggested that they may be involved in the development of lung cancer. These highly expressed cytokines may be used for the diagnosis of lung cancer, and may provide new targeting for the research of lung cancer treatment.

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    Project Supported:
    Project supported by the National Natural Science Foundation of China ( No.81272696)

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