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Archive > Volume 24 Issue 6 > 2017,24(6):656-659. DOI:10.3872/j.issn.1007-385X.2017.06.014 Prev Next
Clinical Research
Prognostic value of serum anterior gradient 2 level before and after surgery in patients with bladder cancer
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Abstract:
Objective:To determine the change of serum anterior gradient2 (AGR2) level before and after surgery in bladder cancer patients, and to investigate its significance in predicting prognosis. Methods:The peripheral venous blood samples were collected from 40 patients with bladder cancer who accepted surgery (bladder cancer group) and 20 healthy controls (control group).The level of serum AGR2 was detected by enzyme linked immunosorbent assay (ELISA). The relationship between the level of serum AGR2 and clinicopathologic characteristics as well as prognosis prediction of bladder cancer was analyzed. Results: The level of serum AGR2 in the patients with bladder cancer was significantly higher than that in normal controls (\[28.93±6.03\] vs \[10.20±3.76\] ng/ml, P<0.01\]. The preoperative level of serum AGR2 in the patients was significantly lower than that of postoperative level (\[16.63±4.31\] vs \[28.93±6.03\] ng/ml, P<0.01). The preoperative level of serum AGR2 was closely correlated with lymph node metastasis and clinical pathologic staging (P<0.01 or P<0.05). The median progression free survival (PFS) and median overall survival (OS) in high level of serum AGR2 group (AGR2＞27.90 ng/mL group) were lower than those in low level of serum AGR2 group (AGR2≤27.90 ng/ml group), respectively (all P<0.05). COX multivariance regression model showed that clinical stages, lymph node metastasis and different level of serum AGR2 were independent risk factors that influence the prognosis of bladder cancer patients (P<0.05). Conclusion: Serum AGR2 in bladder cancer patients was higher, which closely related to malignant biological behavior of bladder cancer. It is of clinical significance to detect the level of serum AGR2 before operation for judging the prognosis of patients with bladder cancer.
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