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Archive > Volume 24 Issue 7 > 2017,24(7):693-699. DOI:10.3872/j.issn.1007-385X.2017.07.001 Prev Next
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Analysis of present situation and future of cancer immunotherapy from the perspective of tumor microenvironment
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Abstract:
The studies of immune checkpoint represented by programmed death 1(PD-1) have pushed cancer im-munotherapy to a climax, which implies that modulating the negative immune regulatory pathway could create an ef-fective munotherapy strategy. Meanwhile, the tumor icroenvironment plays an important role in suppressing or enhancing immune response. Therefore, it will provide new immunotherapy strategy, and make foundation for indi-vidualized precision medicine, based on the mechanism of interation between immune response and tumor microen-vironment. This review summarized the research progress of cancer immunotherapy from the perspective of how the tumor microenvironment affects immune response, and aimed to propose a new strategy for cancer immunotherapy.
Keywords:
Project Supported:
Project supported by the National Natural Science Foundation of China （No.81672275），and the Technology Action Plan on Prevention and Treatment of Major Diseases of the National Health and Family Planning Commission of China （No.2016ZX-07-002）
Clc Number:
