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Archive > Volume 24 Issue 7 > 2017,24(7):716-720. DOI:10.3872/j.issn.1007-385X.2017.07.004 Prev Next
Monographic Report
Expression of GRHL3 and c-Myc in esophageal squamous cell carcinoma tissue and its clinical significance
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Abstract:
Objective: To study expression situation of GRHL3 and c-Myc in the neoplastic and para-carcinoma tis- sues of the patients with esophageal squamous cell carcinoma (ESCC) and its clinical significance. Methods: Patho- logical confirmed neoplastic and para-arcinoma tissues of the 64 patients with ESCC who were hospitalized in De- partment of chest surgery, the Fourth Hospital of Hebei Medical University for tumor resection during April 2015 to July 2016 were collected. Real-time PCR and immunohistochemistry assays were used to detect expressions of mRNA and proteins of GRHL3 and c-Myc genes. Relationship of the expressions of mRNA and proteins of GRHL3 and c-Myc genes with clinical features of the patients with ESCC were analyzed. Results: Comparing with the para- carcinoma tissues, positive expression levels of GRHL3mRNA and GRHL3 protein in the ESCC tissue were obvi-ously raised (mRNA: 2.85 ± 2.83 vs 2.06 ± 2.02, protein: 81.30% vs 25.00%, all P<0.01), positive expression levels of cMyc mRNA and cMyc protein in the ESCC tissue also significantly risen (mRNA: 5.13 ± 5.11 vs 2.03 ± 2.00, protein: 42.20% vs 20.30%, all P<0.01). In the ESCC tissue, expression of GRHL3mRNA and expression of cMyc mRNA were positively correlated obviously (P<0.05), expression of GRHL3 protein and expression of cMyc protein were also positively correlated significantly (P<0.01). Expressions of GRHL3 and cMyc proteins were related to tumor in-filtration range, lymph node metastasis, clinical staging and differentiation degree of the patients with ESCC (all P<0.05). Conclusion: Expression levels of GRHL3 and cMyc in the neoplastic tissues of the patients with ESCC were significantly raised, positive correlation was found between the both expressions, the both expressions were closelyrelated to partial clinicopathological features of the patients with ESCC, which could be key factors that affecting pathological process of the ESCC.
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Project Supported:
Project support- ed by the Young Scientists Program of the National Natural Science Foundation of China (No.H2012206135)，and the Natural Science Foundation of He- bei Province（No. H2014206320）
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