Mobile website
Archive > Volume 24 Issue 7 > 2017,24(7):767-772. DOI:10.3872/j.issn.1007-385X.2017.07.012 Prev Next
Clinical Research
Expression level of costimulatory molecules in peripheral blood of the patients with nasopharyngeal carcinoma and its clinical significance
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective ：To test expression levels of programmed death-1(PD-1) and costimulatory 4-1BB mole-cules on surface of T cells in peripheral blood of the patients with nasopharyngeal carcinoma and to explore their clinical significance in immunotherapy of the patients with nasopharyngeal carcinoma. Methods: Thirty patients with nasopharyngeal carcinoma who were pathological diagnosed and hospitalized in Cancer Hospital of Fujian Province during October to November 2016 were selected as objects of the research, and 30 healthy individuals who are similar to the research objects in gender and age and took physical examination in a medical examination center of the same hospital during the same period as a control group. Expressions of PD-1 and 4-1BB on surface of T cells in peripheral blood as well as ratio of T lymphocyte subgroups were detected by a flow cytometry as-say. Using nuclear magnetic resonance scanning, volumes of the primary carcinoma were measured. Results: Ra-tio of CD8 + T cell in peripheral blood of the patients with Ⅲ stage of nasopharyngeal carcinoma was obviously lower than that of the patients with Ⅳ stage of nasopharyneal carcinoma ([13.1 ± 6.2]% vs [18.7 ±5.5]%,P<0.05).Comparing with the control group, positive expression rate of PD-1 on CD4 + T cell in the research group was sig-nificantly up-regulated([8.7 ± 6.5]% vs [3.87 ± 3.0] %, P<0.05). Expression levels of PD-1 and 4-1BB on surface of T cells in peripheral blood of the patients with nasopharyngeal carcinoma did not obviously correlated with clini-cal staging, tumor load, gender and age of the patient (P>0.05). Conclusion: There could be a synergistic effect between the two costimulatory molecules, PD-1 and 4-1BB, in an immune escape process of tumor. Joint interven-ing a signaling pathway of these two co-stimulation molecules might have more effective and durable antitumor effects，which might provide a novel ideal for an immunotherapy of the nasopharyngeal carcinoma.
Keywords:
Project Supported:
Proj-ect supported by the Natural Science Foundation of Fujian Province(No. 2015J01380), the National Key Clinical Specialty Discipline Construction Foundation of China (2013), and the Key Clinical Specialty Discipline Construction Foundation of Fujian Province(2012)
Clc Number:
