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Archive > Volume 24 Issue 7 > 2017,24(7):773-777. DOI:10.3872/j.issn.1007-385X.2017.07.013 Prev Next
Clinical Research
Expression of lncRNA RP5- 1185K9.17 in cancer tissues of the patients with colorectal cancer and its clinical significance
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Abstract:
Objective: To explore expression of long non-coding RNA (lncRNA) RP5-1185K9.17 in colorectal can-cer tissue and its clinical significance. Methods: Expression of lncRNA RP5-1185K9.17 in surgery removed cancer tissues and corresponding paracancerous tissues of the patients with colorectal cancer who hospitalized in the Sich-uan Provincial People's Hospital during January 2011 to June 2016 were detected by qRT-PCR assay. Chi-Square in-spection, Kaplan-Meier assay and Cox proportional analysis model were used respectively to analyze relationships of the lncRNA RP5-1185K9.17 expression with clinicopathological parameters, survival time and prognosis of the patients with colorectal cancer as well as factors effecting prognosis of the patients. Results: Expressions of ln-cRNA RP5-1185K9.17 in the colorectal cancer tissues were more significantly heightened than that in paracancer-ous normal tissues ([colon cancer: 6.850±0.420; rectal cancer: 7.180±0.380] vs [paracancerous tissue: 1.080±0.220;normal tissue: 0.980±0.140], P<0.01). The expression of lncRNA RP5-1185K9.17 was obviously related to TNM staging, lymph node metastasis, distant metastasis, tumor differentiation, serum CEA level and survival state of the patients (all P<0.05), but not related to gender, age and tumor location of the patients (all P>0.05). Overall survival (OS) and progression free survival (PFS) of the patients with high expression of lncRNA RP5-1185K9.17 were obvi-ously shorten than those of the patients with low expression of lncRNA RP5-1185K9.17 (OS:[25.45±4.28] month vs [42.69±3.72] months; PFS:[13.88±2.97] months vs [26.65±5.33] months, all P<0.01). Expression of lncRNA RP5-1185K9.17, distant metastasis, TNM staging and serum CEA level were independent factors effecting prognosis of the patients (all P<0.05). Conclusion: lncRNA RP5-1185K9.17 could be involved in occurrence and development of the colorectal cancer, and might be a potential molecular marker of diagnosis and prognosis of the patients with colorectal.
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