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Archive > Volume 24 Issue 8 > 2017,24(8):875-879. DOI:10.3872/j.issn.1007-385X.2017.08.010 Prev Next
Clinical Research
Expression of ZIC1 and its prognostic value in human endometrial cancer
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Abstract:
Objective: The aim of this study was to determine the expression of zinc finger protein of the cerebellum 1 (ZIC1) in endometrial cancer tissues, and to investigate its correlation to clinical parameters as well as it prognostic value. Methods: We selected 43 endometrial cancer patients from Kunshan First People’s Hospital Affiliated to Ji-angsu University and Shanghai No.6 People’s Hospital during January 2008 to November 2011, and collected tumor tissues and corresponding para-carcinoma tissues (2 cm or more away from the primary lesion). Immunohistochemis-try, Western blotting and RT-PCR were used to determine the expressions of ZIC1 in 43 endometrial cancer samples as well as the normal adjacent tissues; the association between ZICI expression and clinicopathological parameters were analyzed, and its prognostic value was investigated through 5-year survival analysis. Results:Asignificantly in-creased expression of ZIC1 was observed in endometrial cancer tissues compared to that in para-carcinoma tissues,for both mRNAand protein levels through RT-PCR and Western blotting (P<0.05). ZIC1 was highly expressed in en-dometrial cancer samples with a positive rate of 72.1% (31/43), while the positive rate in para-carcinoma tissues were 39.5% (17/43). Moreover, ZIC1 mRNAwas significantly correlated with lymph node metastasis and FIGO stag-ing (P<0.05); the 5-year survival of ZIC1 - patients was significantly higher than that of ZIC1+patients (66.7% vs 38.7%，P<0.05). Univariant analysis revealed that the hazard ratio (HR) of ZIC1 (high expression vs low expression)was 2.66, 95%CI: 1.07-5.89，P=0.047; and after the adjustment of multivariate analysis, the result showed HR=2.25，95%CI: 1.36-3.71，P=0.002, indicating high level ZIC1 was closely related to the poor prognosis after endometrial surgery. Conclusions: ZIC1 plays an important role in the occurrence and development of endometrial adenocarcino-ma and may be served as a promising target for the therapy and prognosis of endometrial adenocarcinoma.
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Project Supported:
Project supported by the Medical Clinical Science and Technology Development Program of Jiangsu University （No. JLY20120050）
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