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Archive > Volume 24 Issue 8 > 2017,24(8):884-888. DOI:10.3872/j.issn.1007-385X.2017.08.012 Prev Next
Clinical Research
Expression and clinical significance of lncRNA NCRNA00173 in osteosarcoma tissues
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Abstract:
Objective: To investigate the expression and clinical significance of lncRNA NCRNA00173 in the tis-sues of osteosarcoma patients. Methods: The expression of lncRNA NCRNA00173 mRNA was detected in 54 cases of osteosarcoma tissues and adjacent tissues (collected from the patients underwent surgery between October, 2012 and December, 2016 at the Department of Orthopedic, Sichuan Provincial People’s Hospital) by real-time fluores-cence quantification PCR, and its clinical significance was analyzed. Results: The expression of lncRNA NCRNA00173 in osteosarcoma tissues was obviously decreased compared with that in paracarcinoma tissues (1.793±0.158 vs 5.368±0.285，t=10.96，P<0.01). LncRNA NCRNA00173 expression was not significantly correlat-ed with patients’gender or age (both P>0.05), but remarkably correlated with disease stage, distant metastasis, tu-mor differentiation and the survival (all P<0.05); Furthermore, patients with high lncRNA NCRNA00173 expres-sion had significant longer OS and median PFS. Cox multivariate regression analysis suggested that lncRNA NCRNA00173 expression, distant metastasis and clinical stage were the independent prognostic factors for osteosar-coma (P<0.05). Conclusion: lncRNA NCRNA00173 is involved in the occurrence and development of osteosarco-ma, and can be used as a molecular marker for the diagnosis and prognosis of osteosarcoma.
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Project support by the Science and Technology Program of Sichuan (No.2012SZ0181)
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