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Archive > Volume 24 Issue 8 > 2017,24(8):889-894. DOI:10.3872/j.issn.1007-385X.2017.08.013 Prev Next
Clinical Research
Expression and clinical significance of lncRNA CRNDE in patients with non-small cell lung cancer
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Abstract:
Objective: To investigate the expression and clinical significance of lncRNA CRNDE (colorectal neo-plasia differentially expressed) in NSCLC(non-small cell lung cancer) tissues. Methods: 137 cases of NSCLC tis-sues and corresponding para-cancerous tissues from patients with NSCLC who underwent radical or palliative resec-tion in General Hospital of Chengdu Military Region from January 1，2011 to December 31, 2015 were collected for this study; Meanwhile, 29 cases of normal lung tissues from patients suffered from traumatic injury were used as controls. The expression of lncRNA CRNDE in 137 cases of NSCLC tissues and adjacent tissues were detected by QRT-PCR method, and the relationship between its expression and clinical pathological characteristics and progno-sis of NSCLC were analyzed. Results: Compared with the para-cancerous tissues (1.098±0.082), the average expres-sion level of lncRNA CRNDE in cancer tissues (5.283±0.245) was significantly higher with statistical significance (t=14.59, P<0.001). lncRNA CRNDE expression was significantly correlated with disease stage, distant metastasis,pathological type and survival status (all P<0.05), but not associated with age, gender, smoking, tumor size, lymph node metastasis and tumor difference (all P>0.05). The high lncRNA CRNDE expression was related to the patho-logical type of NSCLC (P< 0.05), and the expression of lncRNA CRNDE in adenocarcinoma group was significant-ly higher than that in squamous cell carcinoma and other groups. Moreover, Kaplan-Meier analysis demonstrated that the progression-free survival time in patients with high lncRNA CRNDE expression (20±1.72 months) was shortened compared with the patients with low expression (34.07±1.97 months), the difference was statistically sig-nificant (χ 2 =15.940, P<0.001); the overall survival time of patients with low lncRNA CRNDE expression (47.50±2.31 months) was significantly prolonged compared with those patients with high expression (32.15±2.19 months),the difference was statistically significant (χ 2 =12.40, P=0.004). Cox multivariate survival analysis also indicated that lncRNA CRNDE expression, distant metastasis, clinical stage were the independent prognostic markers for NSCLC (P<0.05). Conclusion: lncRNA CRNDE is involved in the occurrence and development of NSCLC, and can be used as a biomarker for the diagnosis and prognosis of non-small cell lung cancer.
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Project Supported:
Project supported by the National Natural Science Foundation of China （NO.81171869）
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