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Archive > Volume 24 Issue 8 > 2017,24(8):895-899. DOI:10.3872/j.issn.1007-385X.2017.08.014 Prev Next
Clinical Research
Expression of HuR protein in gastric cancer tissues in Xinjiang uygur patients and its clinical significance
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Abstract:
Objective: To detect the expression of HuR (human antigen R) protein in normal gastric mucosa and gastric cancer tissues of Uygur population, and to analyze the relationship between HuR protein and clinicopatholog-ical factors of gastric cancer. Methods: Thirty cases of paraffin embedded gastric tissue samples and 23 cases of cor-responding normal gastric mucosa specimens from First People's Hospital of Kashgar region were collected for this study. The expression levels of HuR in gastric cancer tissues and normal gastric mucosa tissues were examined by tissue microarray and immunohistochemistry SP method; concentrations of AFP, CEA, CA199 and SCC in serum of the patients with gastric cancer were examined by electrochemical luminescence assay. The relationship between HuR expression and clinicopathological characteristics as well as expression of tumor markers in gastric cancer pa-tients were analyzed. Results: HuR was expressed both in the cytoplasm and nucleus of the gastric cancer cells. The positive expression of HuR in nucleus of gastric cancer cells was 83.33%, which was significantly higher than that in normal gastric mucosa cell (52.17%, P<0.05); However, the protein expression was not correlated with the clini-copathological stage of gastric cancer. HuR expression in cytoplasm of gastric cancer cells was 70%, which was sig-nificantly higher than that in normal gastric mucosa (34.78%, (P<0.05), and was correlated with lymph node metas-tasis and clinical stage (P<0.05); In addition, its expression was associated with tumor marker CA199 (P<0.05). Conclusion: In Uygur population, the expression of HuR is highly expressed in the nuclei and cytoplasm of gastric cancer cells, which is significantly higher than that in normal gastric mucosa cells. Moreover, HuR expression in cy-toplasm is associated with lynphonode metastasis, clinical staging and tumor marker CA199.
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Project Supported:
Project supported by the Basic Research forApplication of Xinjiang Province (No. 2015AG015)
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