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Archive > Volume 24 Issue 9 > 2017,24(9):990-994. DOI:10.3872/j.issn.1007-385X.2017.09.011 Prev Next
Clinical Research
Effects of tocilizumab regimen on cytokine release syndrome for patients with relapsed or refractory multiple myeloma treated by CAR-T cell immunotherapy
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Abstract:
Objective: To observe the therapeutic effect of tocilizumab on cytokine release syndrome (CRS) for pa-tients with relapsed or refractory multiple myeloma (MM) treated by CAR-T cell immunotherapy. Methods: From February 2016 to February 2017, 24 patients with relapsed or refractory multiple myeloma treated by CAR-T cell immunotherapy in the Department of Hematology of Second Affiliated Hospital of Medical College, Xi’an Jiaotong University were included as study subjects. Tocilizumab (4-8 mg/kg·d) was applied on MM patients with grade 2 or above , and the treatment efficacy, side effects, and the changes of hypersensitive C-reactive protein (HsCRP) etc were observed. Results: Twenty-one of the 24 patients suffered from CRS during the CAR-T treatment. According to the CRS classification criteria, 7 patients had grade 1 CRS reaction, 7 patients with grade 2, 5 patients with grade 3, and 2 patients with grade 4. The manifestations of CRS were hyperpyrexia, significant increase in cytokines and HsCRP level with the most obvious increase in IL-6. Fourteen CRS patients with grade 2 or above were treated by tocilizumab and their clinical symptoms were obviously alleviated: the temperature was rapidly decreased and cyto-kines and hypersensitive C-reactive protein dropped to normal gradually. In the process of treatment, no obvious side effects were observed. Conclusion: Tocilizumab showed a significant clinical efficacy in the treatment of CRS,which greatly guaranteed the safety of the MM patients in the CAR-T treatment.
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Project Supported:
Project supported by the Major Medical and Technical Pro-grams of SecondAffiliated Hospital of Medical College, Xi’an Jiaotong University(No. XJS201601)
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