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Archive > Volume 24 Issue 9 > 2017,24(9):1010-1015. DOI:10.3872/j.issn.1007-385X.2017.09.015 Prev Next
Clinical Research
Interleukin-10 gene - - 1082A＞ G polymorphism and non-Hodgkin lymphoma susceptibility: a Meta-analysis
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Abstract:
Objective: To assess the association between interleukin-10 (IL-10) gene -1082A＞G polymorphism and non-Hodgkin lymphoma (NHL) susceptibility using Meta-analysis. Methods: Case-control studies about IL-10 gene -1082A＞G polymorphism and NHL susceptibility were searched in PubMed, EMBASE, Web of Science,Chinese Biomedical Literature Database, Chinese Science and Technology Academic Journal, Chinese Journal Full-text Database and Wanfang Database from their inception toJanuary 2017. Meta-analysis was performed using STA-TA 12.0 software. Results: A total of 16 case-control studies were included in this Meta-analysis, including 4 718cases and 3 877 controls. There was association between IL-10 gene -1082A＞G polymorphism and NHL suscepti-bility inallele genetic model (Avs G: OR=1.12, 95%CI=1.04-1.21)，codominant model (AA vs AG: OR=1.27, 95%CI=1.06-1.52) ，additive model (AAvsGG:OR=1.22,95%CI=1.06-1.40) and dominant model (AA vs AG+GG: OR=1.29, 95%CI=1.08-1.53)，but no association with NHL susceptibility in recessive model (GG vs AA+ AG:OR=1.11,95%CI=0.92-1.34). Conclusion: IL-10 gene -1082A＞G polymorphismmay be associated with NHL Susceptibility.
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