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Archive > Volume 24 Issue 10 > 2017,24(10):1118-1123. DOI:10.3872/j.issn.1007-385X.2017.10.013 Prev Next
Clinical Research
Expressions and clinical significance of PD-1 and PD-L1 in peripheral blood of pa-tients with esophageal squamous cell carcinoma
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Abstract:
Objective：To evaluate the expressionlevelsofprogrammeddeath-1 (PD-1), programmeddeathligand-1 (PD-L1) and IFN-γ in the peripheral blood of patients with esophageal squamous cell carcinoma (ESCC), and to ex-plore their clinical implications. Methods：A total of 90 ESCC patients (including 50 patients that underwent surgi-cal treatment) and 40 healthy controls were enrolled in the study. The periphery blood samples of the participants were collected and the expression levels of soluble PD-1 (sPD-1), soluble PD-L1 (sPD-L1) and IFN-γ in the serum were tested by enzyme-link immunology method. The data were tested and analyzed with SPSS 24.0 software. Re-sults：The expression levels of sPD-1,sPD-L1 and IFN-γ in the blood of ESCC group were significantly higher than those in the healthy controls (P<0.05); the preoperative level of sPD-L1 and IFN-γ in ESCC patients was significant-ly higher than that of postoperative level (P<0.05), whereas no significant difference was observed in the expression levels of sPD-1 before and after the surgery (P>0.05). sPD-1 and sPD-L1 expression had no remarkable correlation with clinicopathological manifestations (P>0.05); however, IFN-γ expression was related to lymph node metastasis (P<0.05), but not with other manifestations (T stage, TNM stage, tumor size, tumor location, tumor cell differentia-tion, sex, and age) (P>0.05). The expression level of sPD-L1 had no significant correlation with IFN-γ (P>0.05).Conclusion：The serum level of sPD-L1 was higher in ESCC patients than that in healthy controls, and the post-op-erative sPD-L1 level was decreased compared with pre-operative level, indicating sPD-L1 may be associated with ESCC development.
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