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Archive > Volume 24 Issue 10 > 2017,24(10):1124-1128. DOI:10.3872/j.issn.1007-385X.2017.10.014 Prev Next
Clinical Research
Role of peripheral neutrophil/lymphocyte ratio in the diagnosis and recurrenceprediction of epithelial ovarian cancer
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Abstract:
Objective:To examine the application value of preoperative blood neutrophil to lymphocyte ratio (NLR) in the diagnosis and recurrence prediction of epithelial ovarian cancer (EOC). Methods: The complete clini-cal and pathological information of 147 patients with benign ovarian tumor and 134 patients with EOC that treated in Affiliated Hospital of Qingdao University between January 2003 and January 2011 were retrospectively studied.The optimum cut-off value of the preoperative NLR to diagnose EOC was identified through receiver operator char-acteristic (ROC) curve, and the patients were then classified into two groups according to this cut-off value. Univari-ate and multivariate analyses were performed to assess the high risk factors for the relapse of EOC within 5 years.Results: The optimal cut-off value of NLR was 2.04 to diagnose EOC. There were statistically significant differenc-es in age, CA125 levels, FIGO staging, lymphatic metastasis and ascites formation between the NLR<2.04 group and the NLR≥2.04 group (P<0.05), but no significant discrimination was observed in pathological type and differen-tiation level (P>0.05). Univariate and multivariate analyses revealed that NLR ≥2.04 was a risk factor the relapse of EOC within 5 years (P<0.05). Conclusion: An elevated preoperative NLR value was correlated with EOC and mul-tiple clinical indicators, which is an important independent relapse predictor for patients with EOC.
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Project Supported:
Project supported by the Scientific and Technological Development of Qingd-ao South District(No.2014-14-031-YY)
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