Mobile website
Archive > Volume 24 Issue 11 > 2017,24(11):1247-1253. DOI:10.3872/j.issn.1007-385X.2017.11.001 Prev Next
Expert Forum
Dysfunction of T cell in tumor microenvironment and strategy of reversing the dysfunction
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
T cell dysfunction in tumor microenvironment is the key mechanism of tumor escaping from immune surveillance. T cell dysfunction induced by up-regulating expression of immune checkpoint molecules is a hot point of the current research. The clinical trials of blocking immune checkpoint, PD-1 and CTLA-1, have shown encouraging efficacy in the many patients with advanced cancer. It was confirmed that there was T cell dysfunction in tumor microenvironment and reversing T cell dysfunction could play a potentiality in tumor therapy. However, the novel immunotherapy methods exhibited a long-lasting clinical efficacy in a small number of the patients with cancer only,which suggest heterogeneity and complexity of the tumor microenvironment. Recently, the research in unicellular level further clarified phenotypic characteristics and clinical significance of T cell dysfunction in tumor microenvironment, which reveals that epigenetics and metabolic changes are the important mechanisms resulting in T cell dysfunction in the tumor microenvironment and suggests the novel methods for reversing T cell dysfunction in the tumor microenvironment. This paper focus on the latest research progresses of the T cell dysfunction in the tumor microenvironment and strategy of reversing the T cell dysfunction.
Keywords:
Project Supported:
Project supported by the National Natural Science Foundation of China (No.31100641, No.31270946), and the Basic and Advanced Technology Research Program of Henan Province (No. 142300410387)
Clc Number:
