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Archive > Volume 24 Issue 11 > 2017,24(11):1304-1308. DOI:10.3872/j.issn.1007-385X.2017.11.011 Prev Next
Clinical Research
Expression of extracellular matrix protein spondin2 in human gastric carcinoma tissue and its clinical significance
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Abstract:
Objective: To explore expression of extracellular matrix protein spondin2 (SPON2) in human gastric carcinoma tissue and its relationship with occurrence of the gastric carcinoma. Methods: Gastric adenocarcinoma and para-carcinoma tissues of 75 patients who hospitalized in Zhangjiagang Hospital affiliated to Suzhou University for eradication of the gastric carcinoma during June 2014 to July 2016 were collected. Immunoflorescence staining was used to survey localization of SPON2 protein in cells of the gastric carcinoma and the para-carcinoma tissues.Expressions of SPON2 in the gastric carcinoma and the para-carcinoma tissues were detected by immunohistochemical staining. Relationship between expression of SPON2 protein and clinicopathological features of the patients with gastric carcinoma was analyzed. Results: SPON2 protein was localized in cytomembrane, cytoplasm and extracellular matrix of the gastric carcinoma cells. Expression of SPON2 protein in the gastric carcinoma tissue was significantly higher than that in the para-carcinoma tissue (72.0% vs 16.0%, P<0.01). There was no relationship between expression of SPON2 protein and tumor cell differentiation, gender, age of the patients with gastric carcinoma, as well as there were significant relationships between expression of SPON2 protein and tumor size, TNM staging, invasion degree, lymph node metastasis (all P<0.05). Conclusion: High expression of SPON2 protein in the gastric carcinoma tissue was related to occurrence and development of the gastric carcinoma, which suggests that SPON2 protein might become a novel marker of early clinical diagnosis and a potential therapeutic target of the gas-tric carcinoma as well as could forecast prognosis of the patients with gastric carcinoma.
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Project Supported:
Project supported by the Foundation of Suzhou City for Key Medical Diagnosis and Treatment Project (No. LCZX201617)
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