Mobile website
Archive > Volume 24 Issue 12 > 2017,24(12):1397-1402. DOI:10.3872/j.issn.1007-385X.2017.12.010 Prev Next
Clinical Research
Expression and clinical significance of hnRNPA1 in neoplasms of digestive system
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective：To investigate the expression patterns of hnRNPA1 mRNA in the digestive system tumors and its clinical significance. Methods：Whole genome mRNA sequencing data of TCGA databases were used to analyze the different expression of hnRNPA1 in tumor and normal tissues and to study its correlation to clinical pathological data; and survival analysis was performed to determine its prognostic value. Results：1. The expressions of hnRNPA1 were significantly higher in digestive system tumor tissues than that in normal tissues（P<0.01），especially in colorectal cancer, hepatocellular carcinoma, pancreatic cancer and cholangiocarcinoma. 2. In hepatocellular carcinoma,hnRNPA1 expression was correlated with tumor differentiation, TNM stage and the depth of invasion (all P<0.05), but not associated with age, sex, risk factors of liver cancer. In pancreatic cancer and cholangiocarcinoma, the expression of hnRNPA1 was not significantly associated with age, sex, TNM stage and infiltration depth etc. 3. The expression of hnRNPA1 was correlated with overall survival in pancreatic cancer patients (P<0.05), which is a risk factor for the prognosis that independent of TNM stage, degree of differentiation; the expression of hnRNPA1 was not significantly associated with overall survival in colorectal cancer, hepatocellular carcinoma and cholangiocarcinoma.Conclusion：The expression of hnRNPA1 mRNA was increased in tumor tissues of different digestive system cancers; its over- expression is an independent risk factor for the prognosis of pancreatic cancer, which might be served as a potential biomarker for predicting prognosis.
Keywords:
Project Supported:
Project supported by the National Natural Science Foundation (No.81370484）
Clc Number:
