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Influence of DC-CIK on circulating tumor cells in patients with liver metastasis after radical resection of colorectal cancer and its therapeutic efficacy
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Abstract:
Objective: To explore and identify the influence of dendritic cell-cytokine induced killer cell （DC-CIK）on the number of blood circulating tumor cell (CTC), therapeutic efficacy and prognosis of patients with liver metastasis after radical resection of colorectal cancer. Methods: We retrospectively analyzed the clinical data of patients developing liver metastasis after radical resection of colorectal cancer (CRC) and treated in PLA 309th Hospital between July, 2009 and December, 2015, among whom 62 patients were administered DC-CIK plus conventional treatment (DC-CIK group) and 70 received only conventional treatment (conventional group). In addition, peripheral venous blood of 21 patients in DC-CIK group and 24 patients in conventional group were examined to clarify CTC number via CellSearch R immunomagnetic technology. The therapeutic efficacy was compared between the two groups. Results: The CTC number of patients in DC-CIK group decreased significantly after treatment (1.0±1.1 vs 2.7±2.0, P<0.01), while that in conventional group did not alter obviously (P>0.05). The resection rate of liver metastasis, objective response rate to treatment, patients’progression-free survival and overall survival of DC-CIK group were all superior than those of conventional group (P<0.05 or P<0.01).Conclusion: DC-CIK can decrease the number of CTC in CRC patients with liver metastasis after radical operation and prolong their survival; it has reliable anti-tumor effect under the precondition of standard execution.
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Project Supported:
Project supported by the Military Medicine Innovation Program of the Health Department of the General Logistics Department（No. 13CXZ047）
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