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Archive > Volume 25 Issue 2 > 2018,25(2):109-117. DOI:10.3872/j.issn.1007-385X.2018.02.001 Prev Next
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Advances in research of peripheral blood miRNAs in early diagnosis of tumors
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Abstract:
MicroRNA (miRNA) is non-coding RNA molecule consisting of 20-25 nucleotides. It plays an important role in regulation of tumorigenesis and progression, including proliferation, differentiation and apoptosis of cancer cells, which directly affect the progress of tumors. Peripheral blood miRNA is relatively more stable, and easier to acquired and detected than tissue miRNA. It is a new generation biomarker for early detection and early diagnosis of tumors. It is also one of the main development directions of research and application in precision medicine. Methods commonly used in peripheral blood miRNA detection are RT- PCR,electrochemical detection, NanoString Technologies, genechip and high-throughput sequencing etc. Multiple miRNAs in peripheral blood are the early diagnostic markers for non-small cell lung cancer, esophageal squamous cell carcinoma, pancreatic cancer, squamous cell carcinoma of the head and neck, ovarian cancer, colorectal cancer, breast cancer, prostate cancer and hematological malignancies. Combined detection of multiple peripheral blood miRNAs, as well as combined detection of tumor-specific miRNAand serological, imaging and other auxiliary methods, can improve the sensitivity and specificity of tumor diagnosis at early stage.
Keywords:
tumor ; microRNA ; marker ; early diagnosis
Project Supported:
Project supported by National Natural Science Foundation of China (No.81560380, 81460358, 81060177), Joint Special Fund fromYunnan Provincial Science and Technology Department-Kunming Medical University for Applied and Basic Research (No.2014FB066), Project of Medical and Health Technology Development Program of Yunnan Province (No.2014NS023, 2014NS024), Academic Leaders Training Program of Yunnan Provincial Health and Family Planning Commission (No.D- 201601), and the ZHAN Qimin Academician Workstation Project Fund (No.2015IC002)
