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Archive > Volume 25 Issue 4 > 2018,25(4):329-333. DOI:10.3872/j.issn.1007-385X.2018.04.002 Prev Next
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Epithelial-interstitial transformation and invasion of glioblastoma multiforme
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Abstract:
[Abstract] Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. Despite advances in traditional treatment strategies that combine surgery with radiotherapy and chemotherapy, GBM remains one of the most lethal diseases with dismal prognosis. Epithelial-interstitial transformation (EMT) is an important biological process for the invasion and migration of malignant tumors derived from epithelial cells, which is closely related to the pathological behaviors of GBM including invasion, migra- tion, resistance to chemotherapy and radiotherapy. This review will introduce the concept of EMT and its pathophysiological process, especially the latest findings related to the GBM biology. Besides, gene regulation and signaling pathways of EMT (such as matrix me- talloproteinases [MMP], TGF-β, transcription factors Snail and Twist etc.) participated in GBM are also introduced, thereby providing a new insight into the fundamental researches and clinical treatments of GBM.
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Project Supported:
Project supported by the Sub-Project of National Sci-Tech Support Thirteenth Five-Year Plan of China（No. 2016YFC1301800）
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