Advanced research of immune-related response evaluation criteria in solid tumors
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Abstract:
[Abstract] In recent years, therapy of immune checkpoint inhibitors have developed rapidly and made breakthrough, becoming the first-line treatment for many types of advanced cancer. However, due to its particular mode in activating the anti-tumor immune system,a variety of unconventional response patterns have emerged, such as delayed response and pseudoprogression, which have challenged the traditional response evaluation criteria and encouraged people to continuously explore new criteria for evaluating the unconventional response patterns under immunotherapy. This article mainly reviews the process of exploration, advanced research,as well as similarities and differencesamongvarious immune-related efficacy evaluation criteria, and finally prospects the current challenges and future trends.
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Project supported by the National Key Research and Development Program of China(No.2016YFC1303800),the National Natural Science Foundation of China(No.81672275),the Key Laboratory Construction Project of Department of Science and Technology of Jilin Province(No.20170622011JC),the Special Project of Development and Reform Commission in Jilin Province(No. 2017C022),and the Special Project of the National Health and Family Planning Commission of China(No. ZX-07-C2016004)