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Archive > Volume 25 Issue 9 > 2018,25(9):854-858. DOI:10.3872/j.issn.1007-385X.2018.09.002 Prev Next
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New strategies for CAR-T cell in the treatment of solid tumors
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Abstract:
[Abstract] Chimeric antigen receptor modified T (CAR-T) cell, a novel adoptive immunotherapy strategy, has been used successfully against hematological tumors. However, in solid tumors, due to multiple immunosuppressive cells, immunosuppressive molecules, and extracellular matrix play a suppressive role in the cytotoxic effects of migrating CAR-T cells and severely inhibit the antitumor efficacy of CAR-T cells in the tumor microenvironment of solid tumors. Simultaneously, tumor heterogeneity, lacking proper tumor antigens,poor homing ability at solid tumor sites, along with off-target effect, resulting in poor therapeutic effect of CAR-T cells in solid tumors.Compared with hematological tumors, solid tumors have complex biological characteristics, and thus targeted strategies are demanded to ensure long-term efficacy of CAR-T cells against tumors. This review makes a summary of the development of CAR-T cells, the confusion in solid tumors and the progress of treatment strategies.
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Project Supported:
Project supported by the Naional Key R & D Program (No. 2018YFC1313400), the National Science and Technology Supporting Program (No.2015BAI12B12), the Joint Research Fund for Overseas Chinese, Hong Kong and Macao Scholars (No.31729001), the National Natural Science Foundation of China (No.31570877, No.31570908), the Key R&D Project of Science and Technology Department of Jiangsu Province (BE2018645)
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