Mobile website
Archive > Volume 25 Issue 12 > 2018,25(12):1209-1217. DOI:10.3872/j.issn.1007-385X.2018.12.001 Prev Next
Expert Forum
Optimizing CAR structure to improve safety and efficiency of CAR-T cell therapy
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
[Abstract] CAR-T cell therapy has developed rapidly in recent years, and has achieved amazing results in the treatment of some malignant tumors of the blood system, but little progress has been made in the treatment of solid tumors. At present, the main problems to be solved in CAR-T cell therapy are: (1) enhancing the killing activity of CAR-T cells; (2) relieving the immunosuppressive state of tumors;(3) bringing CAR-T cells into solid tumors; (4) enhancing the safety of CAR-T cell therapy. By optimizing the structure of CAR,a series of defects in the CAR-T cell therapy can be overcome, and the curative effect of CAR-T can be enhanced and the complications can be alleviated. In this paper, some optimization and improvement measures and methods on the structure design of CAR in recent years are elaborated, and the effectiveness and safety of the CAR-T cell therapy are explored.
Keywords:
Project Supported:
Project supported by the National Natural Science Foundation of China（No.31171427）, and the Science and Technology Program Foundation of Beijing City（No.Z121107001012136）
Clc Number:
