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Clinical transformation of personalized neoantigen vaccine: opportunities and challenges
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Abstract:
[Abstract] As one of the pivotal immunotherapies, tumor vaccine has increasingly shown its benefits in the treatment of malignant tumors.However, traditional vaccines targeting tumor associated antigen (TAA) are difficult to be promoted on a large scale in clinic, due to immune tolerance and the risk of inducing autoimmune disease. Neoantigen, which doesn’t present in normal cells and originates from tumor somatic mutations, is considered as ideal target for vaccines recently. Personalized neoantigen vaccine developed on the basis of sequencing, which specifically targets neoantigens, is expected to become an important breakthrough in precision medicine of cancer.This paper will elaborate on the concept, characteristics, preparation process and clinical trials of personalized neoantigen vaccine,and we will also discuss the opportunities and challenges that might be encountered during its clinical transformation.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81372249), the Science and Technology Plan Project of Guangzhou (No. 201704020216), the Science and Technology Development Special Foundation of Guangdong Province (No. 2016A 020213005), the National Natural Science Foundation of Guangdong Province (No. 2017A030310301), and the Clinical Research Startup Project of Southern Medical University (No. LC2016ZD027)
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