Project supported by the National Science and Technology Support Project (No. 2015BAI12B12), the National Natural Science Foundation of China (No.31570877, No.31570908), the Hong-Kong and Macao Scholars Cooperative Research Fondation (No.31729901), the Key Research and Development Plan Special Fundation of Jiangsu Province (No. BE2018645), and the Tumor Immunotherapy Engineering Technology Research Center of Jiangsu Province (No.BM2014404)