Project supported by the Health Technology Innovation Project ofJilin Province (No. 2017J064),the Clinical Research and Cultivation Fund of Jilin University First Hospital (No. LCPYJJ2017003), the Jilin Provincial Department of Finance (No. 2018SCZWSZX- 010), and the Science and Technology Development Plan Project of Department from Science and Technology of Jilin Province (No. 20180101009JC)