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Archive > Volume 26 Issue 7 > 2019,26(7):782-787. DOI:10.3872/j.issn.1007-385X.2019.07.010 Prev Next
Clinical Research
Expressions of CMTM6 and PD-L1 protein in glioma tissues and their correlation with clinicopathological characteristics of patients
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Abstract:
[Abstract] Objective: To investigate the expressions of chemokine-like factor superfamily 6 (CMTM6) and programmed cell death ligand 1 (PD-L1) in glioma tissues and their correlation with clinicopathological features of patients. Methods：From January 2012 to December 2015, 86 brain glioma tissues and 30 brain tissues (Control group) from patients operated with decompressive of craniotomy were collected from the Fifth Affiliated Hospital of Zhengzhou University. The distribution and expressions of CMTM6 and PD-L1 protein in brain glioma tissues were detected by immunohistochemistry and WB methods. The differential expression of CMTM6 and PDL1 between glioma tissues and normal brain tissues was analyzed by t test of two independent samples. Single variant χ2 test was used to analyze the relationship between the expression of CMTM6, PD-L1 and the clinicopathological features of patients. Results: The expression of CMTM6 in glioma tissues was significantly higher than that in control tissues (P<0.01). The expression levels of CMTM6 and PD-L1 in high pathological grade (WHO III-IV) glioma tissues were significantly higher than those in low pathological grade (WHO I-II) glioma tissues (all P<0.01). The expression of CMTM6 was correlated with pathological grade, dizziness history, epilepsy seizure and PD-L1 expression (all P<0.05), while the expression of PD-L1 was correlated with pathological grade, epilepsy seizure and CMTM6 expression (all P<0.05). Conclusion: There is a correlation between the expression of CMTM6 and PD-L1 in glioma tissues,both of which are highly expressed and are expected to be used to study glioma signaling pathways.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81874068), and the Key Specialized Subject Service Capability Enhancement Plan of Henan Province (No.2017-56)
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