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Archive > Volume 26 Issue 10 > 2019,26(10):1053-1061. DOI:10.3872/j.issn.1007-385X.2019.10.001 Prev Next
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Application and prospect of nano-antibody in the diagnosis and treatment of cancers
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Abstract:
[Abstract] Nano-antibodies (Nbs) were first discovered in the peripheral blood of alpacas. Compared with traditional antibodies, Nbs have the characteristics of small volume, good stability, strong tissue permeability, and easy production through microbial systems, etc.They are currently the smallest known functional antigen-specific binding fragments. Therefore, Nbs have been considered as valuable proteins in recent years and widely used in many fields, such as basic research, new drug development, disease treatment and so on.This article reviews the structural and biochemical properties of Nbs and the research progress on Nbs in the fields of tumor diagnosis and treatment, as well as their application prospect.
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Project Supported:
Project supported by the National “12th Five-Year”Plan for Major New Drug Creation Science and Technology (No. 2013ZX09103003-002), and National“Eleventh Five-Year Plan”Major New Drug Creation Technology Sub-project (No. 2009ZX09503-010), and the National Natural Science Foundation of China (No. 30771103, No.81172792, No. 81101605, No. 81573467)
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