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Archive > Volume 26 Issue 11 > 2019,26(11):1181-1188. DOI:10.3872/j.issn.1007-385X.2019.11.001 Prev Next
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Roles of microRNAs in the tumor progression promoted by cancer-associated fibroblasts
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Abstract:
Cancer-associated fibroblasts (CAFs) are one of the major cellularcomponents in tumor microenvironment (TME), which play an important role in cancer progression. MicroRNAs (miRNAs) could participate in the process of CAFs, transformation and metabolism reprogramming, affect the stemness of CAFs, and regulate CAFs-mediated tumor cell proliferation, invasion and chemotherapy resistance; and studies have shown that miRNAs play an important role in CAFs formation and the regulation of CAFs on tumors.The miRNAs released by CAFs can be used as reference indicators for tumor diagnosis, prognosis and drug selection. Thus, exploring the role of miRNAs in the interaction between CAFs and tumor cells and underlining the mechanism, is of great significancefor understanding the occurrence and development of tumors, as well as providing novel strategy for cancer treatment. This review will summarize the role of miRNAs in the formation of CAFs and the regulation of CAFs on tumor cells.
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Project Supported:
Supported by the National Natural Science Foundation of China (No. 81372519), the Specialized Research Foundation for the Doctoral Program of Higher Educational of China (No. 20131202110005), and the Key Project of Natural Science Foundation of Tianjin Ctiy (No.18JCZDJC98500)
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