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Archive > Volume 28 Issue 2 > 2021,28(2):103-108. DOI:10.3872/j.issn.1007-385x.2021.02.001 Prev Next
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T lymphocyte homing: a critical factor of adoptive cell therapy for solid tumors
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Abstract:
In recent years, tumor immunotherapy has developed rapidly, among which T-cell-based adoptive cell therapy has achieved certain clinical effect and become one of the most potential immunotherapeutics. T cell infiltration mainly includes rolling, adhesion, extravasation and chemotaxis etc. However, there are physical barriers, chemokine mismatch, vascular abnormalities, immunosuppressive microenvironment and other factors that limit the efficacy of adoptive cell therapy. The homing ability of T cells can be further improved by optimizing the chemokine receptor on the cell surface, inserting targeted peptide, improving the way of administration, and adopting combined treatment of radiotherapy, immune checkpoint blocker, tumor vaccine and bispecific antibody, etc. This review mainly summarizes the process of T cell infiltration, the influencing factors of T cell targeting tumor site and the relevant treatment strategies, as well as gives a prospection for future research.
Keywords:
Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81872146), the Natural Science Foundation of Jiangsu Province (No. BK20191114), and the Youth Talent Cultivation Project for Health System in Nanjing City (No. QRX17038)
Clc Number:
R730.51；R730.58
