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Predictive value of peripheral blood NLR and PLR in perioperative period on the prognosis of patients with intrahepatic cholangiocarcinoma
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Abstract:
Objective: To investigate the predictive value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to[1]lymphocyte ratio (PLR) in perioperative period on the prognosis of patients with intrahepatic cholangiocarcinoma (ICCA). Methods: Ninety-seven cases of ICCA patients underwent liver resection surgery in Songjiang District Central Hospital from January 2015 to January 2018 were chosen as the ICCA group, and 100 healthy volunteers who underwent physical examination in the hospital during the same period were selected as the control group. The NLR and PLR on preoperative day 1, postoperative day 3 and day 7 were compared between the two groups. Univariate and multivariate analyses were performed to determine the risk factors for mortality during postoperative follow-up in patients with ICCA. Kaplan-Meier survival curve was used to analyze the influence of postoperative day 3 NLR and PLR on the survival time of patients with ICCA. ROC curve was used to analyze the predictive value of postoperative day 3 NLR and PLR on the mortality during postoperative follow-up. Results: Peripheral blood NLR and PLR in the ICCA group were higher than those in the normal control group on preoperative day 1 and postoperative day 3, 7 (all P<0.05). In the ICCA group, the peripheral blood NLR and PLR on preoperative day 1 and postoperative day 7 showed no statistical difference (P>0.05); however, the levels on postoperative day 3 was the highest (P<0.05). Multiple tumors, lymph node metastasis, TNM staging Ⅲ - Ⅳ , increased carbohydrate antigen 199 (CA199) level and higher NLR and PLR on postoperative day 3 were the independent risk factors of mortality during postoperative follow-up in ICCA patients (all P<0.05). The ROC showed that NLR and PLR on postoperative day 3 had predictive value for the survival time of patients with ICCA. Kaplan-Meier survival curve showed that the survival time of patients in low NLR group was longer than those in high NLR group [(50.32±3.69) months vs (30.12±2.36) months], and the survival time of patients in low PLR group was longer than those in high PLR group [(53.6±3.75) months vs (37.6±2.96) months] (all P<0.05). Conclusion: Abnormal elevation in NLR and PLR on postoperative day 3 is an independent risk factor for death after liver resection surgery in patients with ICCA, which has early predictive value for patients’survival.
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Project Supported:
Project supported by the National Natural Science Foundation of China （No.81272534, No.30872510）
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