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Archive > Volume 28 Issue 9 > 2021,28(9):920-925. DOI:10.3872/j.issn.1007-385X.2021.09.009 Prev Next
Clinical Research
Levels of PD‑L1 and CD8+ TIL in TNBC tissues and their clinical significance
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Abstract:
Objective: To investigate the level and clinical significance of programmed death ligand-1 (PD-L1) and tumor-infiltrating lymphocyte (TIL) in triple-negative breast cancer (TNBC) tissues. Methods: A total of 61 postoperative paraffin samples of tumor tissues and para-cancerous tissues from TNBC patients who underwent surgical resection during January 2015 and January 2019 were collected from the Second Affiliated Hospital of Fujian Medical University. The PD-L1 expression and CD8+ TIL level were detected by Immunohistochemistry. The relationship between the levels of PD-L1 and CD8+ TIL in TNBC tissues and the clinicopathological features as well as the prognosis of TNBC patients was analyzed by Chi-square test. Results: The positive rate of PD-L1 and CD8+ TIL in TNBC tissues was 63.9% (39/61) and 32.8% (20/61), respectively. The expression of PD-L1 was significantly correlated with tumor diameter, lymph node metastasis, TNM staging and recurrence (all P<0.05), but not significantly correlated with the age of patients, differentiation degree, vascular invasion and Ki67 expression (all P>0.05). The level of CD8+ TIL was significantly correlated with tumor diameter, differentiation degree, lymph node metastasis, TNM staging and recurrence (all P<0.05), but not significantly correlated with the age of patients, vascular invasion and Ki67 expression (all P>0.05). The levels of PD-L1 and CD8+ TIL were significantly correlated with progression-free survival (PFS) and overall survival (OS) of patients (both P<0.05). Positive PD-L1 expression or lack of CD8+ TIL were associated with tumor invasiveness and worse PFS and OS of patients (both P<0.05). Conclusion: High levels of PD-L1 and CD8+ TIL are present in TNBC tissues. The positive expression PD-L1 and lack of CD8+ TIL are both associated with increased tumor invasiveness and worse PFS and OS of patients
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Project Supported:
Project supported by the Youth Project of National Health and Family Planning Commission (No.2018-2-26), and the Science and Technology Project of Quanzhou City (No.2018Z112)
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