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Personalized neoantigen vaccines for tumor immunotherapy: a long hard journey to promising land
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Abstract:
Personalized neoantigen cancer vaccines have gradually emerged, with breakthroughs being made in the treatment of cancers such as melanoma, lung cancer and glioma, demonstrating potential and promising prospects. With the decrease in sequencing costs, continuous breakthroughs in artificial intelligence (AI) technology and the deepened understanding of tumor immunotherapy, it is feasible to conduct dynamic whole-process monitoring and to capture the clone diversity of tumor-related somatic mutations in tumor patients, along with which the developed neoantigen cancer vaccines have become the current research hotspot with promising future. This review systematically summarizes the research context and progress as well as looks into the future key development of the personalized neoantigen cancer vaccines, an emerging precise immunotherapy, from the aspects of screening and validation of neoantigens, clinical application, challenges, and future trends.
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