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Expression and clinical significance of PD-1 and NLRP3 in follicular thyroid carcinoma tissues
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Abstract:
Objective: To investigate the expression of programmed death protein 1 (PD-1) and NOD-like receptor protein 3 (NLRP3) in follicular thyroid carcinoma (FTC) tissues and their relationship with clinicopathological features and prognosis of patients.Methods: A total of 60 pairs of cancer tissues and corresponding para-cancerous tissues that surgically resected from patients with FTC at the Second Affiliated Hospital of Fujian Medical University from January 2015 to June 2020 were collected for this study. The positive expression rate of PD-1 and NLRP3 was detected by immunohistochemical staining in the cancer and para-cancerous tissues.The relationship between the expression of PD-1, NLRP3 and the clinicopathological characteristics of FTC patients was analyzed by χ2 test or Fisher's exact test. Pearson correlation analysis was used to analyze the relationship between the expression of PD-1 and NLRP3,and Kaplan-Meier survival analysis and Logistic regression analysis were used to analyze the relationship between the expression of PD-1, NLRP3 and the prognosis of FTC patients. Results: High positive expression rates of PD-1 and NLRP3 were observed (46.67%and 63.33%) in the FTC tissues. The expression of PD-1 was significantly correlated with tumor stage, tumor diameter, vascular invasion and recurrence status of FTC patients (all P<0.05), while the expression of NLRP3 was significantly correlated with tumor diameter, vascular invasion, extra-thyroid infiltration and recurrence status of the patients (all P<0.05). The expression of PD-1 was negatively correlated with NLRP3 level. PD-1 was correlated with a better prognosis of patients, while NLRP3 was an independent risk factor for disease recurrence. Conclusion: PD-1 and NLRP3 have high positive expression rate in FTC tissues. The former is associated with better prognosis, while the latter is an independent risk factor for disease recurrence, and the two are negatively correlated.
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