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Archive > Volume 29 Issue 3 > 2022,29(3):167-174. DOI:10.3872/j.issn.1007-385X.2022.03.001 Prev Next
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Innovation and combination: iteration and exploration of the best combination of comprehensive cytokine-based cancer immunotherapy
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Abstract:
As an important part of anti-tumor immunity, cytokines were once shining stars in tumor immunotherapy. Standing at the tide of the transformation of cancer immunotherapy strategy, comprehensive cytokine-based cancer immunotherapy has continuously iterated and explored through a variety of the theoretical and technological innovations as well as various optimized combinations, and gradually changed the unsatisfactory effect of tumor monotherapy, so as to create another brilliance and provide a new way for comprehensive tumor immunotherapy. The new understanding of the intercellular communication in tumor microenvironment, the research and development of novel cytokines and modified products for tumor immunity, the discovery of the unique structure of shared signaling receptors and the combination with the new generation of anti-tumor treatment have injected new vitality into the application of tumor cytokine therapy. These findings highlight the guiding role of "innovation and combination" in the design of comprehensive strategy of cytokine-based cancer immunotherapy, and also have a certain reference value for the research and development of other tumor biotherapy technologies.
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Clc Number:
R730.51
