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Archive > Volume 29 Issue 6 > 2022,29(6):519-526. DOI:10.3872/j.issn.1007-385X.2022.06.002 Prev Next
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Attenuated Salmonella-mediated cancer therapy: updates and prospects
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Abstract:
Attenuated Salmonella has shown broad tumor targeting specificity against solid tumors. By activating host antitumor response and modifying tumor immune microenvironment, attenuated Salmonella can suppress tumor development. Meanwhile, the high tumor targeting specificity enables the attenuated Salmonella to be used as the ideal expression and delivery vector for therapeutic drugs and imaging probes, realizing the integration of tumor diagnosis and treatment. Attenuated Salmonella has been widely studied and applied in basic and clinical fields, showing good application prospects and promising future. In this article, we will first investigate the attenuated Salmonella-related antitumor mechanism, application status, current problems and challenges and then explore how to improve its biosafety, tumor targeting specificity, and antitumor efficacy by using genetic biotechnology, thus to promote the translational application of attenuated Salmonella and realize the cross-integration of immunology, biotechnology and other disciplines, which may provide a new strategy and direction for future clinical tumor biotherapy.
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