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Archive > Volume 29 Issue 7 > 2022,29(7):653-658. DOI:10.3872/j.issn.1007-385X.2022.07.007 Prev Next
Clinical Research
Visualization analysis of the role of STING signaling pathway in breast cancer progression based on Citespace
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Abstract:
Objective: To explore the current status, collaboration, hotspots and development trends of domestic and international researches on stimulator of interferon genes (STING) signaling pathway in breast cancer progression from 2009 to 2021. Methods: Using "breast cancer" and "STING" as key words, 122 research papers from core collections were retrieved from Web of Science database and subject to visualization analysis by Citespace software to evaluate the role of STING in regulating breast cancer progression. Results: Since 2016, research papers related to breast cancer and STING have increased rapidly, among which the greatest number of publications came from the United States, with Dana-Farber Cancer Institute ranking the first. Micronuclei produced in DNA strand breakage stimulate the cGAS-STING signaling pathway and can effectively initiate tumor-specific CD8+ T cell anti-tumor immune responses. Key word cluster analysis and analysis of research hotspots and development trends also indicate that anti-tumor immune therapies represented by macrophages are the hot issue in breast cancer and STING related research field. Conclusion: Key molecules in STING signaling pathway will become a new immune target for prevention and treatment of breast cancer.
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