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Archive > Volume 29 Issue 8 > 2022,29(8):701-707. DOI:10.3872/j.issn.1007-385X.2022.08.001 Prev Next
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New strategies for tumor immunotherapy based on pyroptosis
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Abstract:
Pyroptosis is a recently-discovered novel regulatory cell death that plays an important role in tumor immunity. Pyroptosis in cancer progression includes immune cell pyroptosis (ICP) and cancer cell pyroptosis (CCP), which may promote or inhibit cancer. The occurrence of ICP can be mediated by both caspase-1 mediated classical pathway and caspase-4/5/11 mediated non-classical pathway. Inflammasome and cytokines IL-18 and IL-1β play important roles in tumor immunity involving ICP. The occurrence of CCP is mediated by GSDME pathway which can be cleaved and activated by caspase-3 and granzyme B. Spontaneous and persistent CCP promotes tumor growth during tumorigenesis, while GSEME activation-mediated CCP has significant anti-tumor effect during chemotherapy and other processes. Pyroptosis can stimulate inflammatory response in tumor microenvironment, improve immunogenicity of tumor cells and promote the occurrence of anti-tumor immunity. Therefore, pyroptosis and its induced inflammatory response play an important role in tumor immunity. Researches in this field may provide new ideas for anti-tumor immunotherapy.
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