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Archive > Volume 29 Issue 8 > 2022,29(8):750-755. DOI:10.3872/j.issn.1007-385X.2022.08.007 Prev Next
Clinical Research
The clinical significance of TIGIT/CD155 expression in triple negative breast cancer tissues
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Abstract:
Objective: To investigate the expressions of T cell immunoreceptor with Ig and ITIM domain (TIGIT) and CD155 in triple negative breast cancer (TNBC) tissues and their correlations with clinicopathologic features and survival prognosis and to explore their value in the prognosis of TNBC. Methods: A total of 64 eligible female patients who underwent surgical resection and were diagnosed by pathology in the Second Affiliated Hospital of Fujian Medical University from January 2014 to December 2018were enrolled, and their tumor tissues collected. Immunohistochemistry was used to detect the expressions of TIGIT and CD155 in TNBC tissues. The clinicopathological data of the enrolled patients were collected and their survival prognosis was followed up. Chi-square test or Fisher's exact test was used to analyze the relationship between the expressions of TIGIT and CD155 and the clinicopathological characteristics. Kaplan-Meier survival curve, Logrank test and Cox regression analysis were used to investigate the relationship between the expressions of TIGIT and CD155 and the prognosis.Results: The positive expression rates of TIGIT and CD155 in TNBC were 48.4% (31/64) and 79.9%(51/64) respectively. Both TIGIT and CD155 expressions were correlated with tumor size, lymph node metastasis and tumor stage (all P<0.05), but not with age, menstrual status,histological grade, and Ki-67 (all P>0.05). Survival analysis indicated that both TIGIT and CD155 expressions were significantly associated with poor DFS (all P<0.05), but they were not independent prognostic risk factors for TNBC. Multivariate analysis showed that only TNMstaging was an independent prognostic risk factor for TNBC patients (P<0.05). Conclusion: TIGIT and CD155 are highly expressed in TNBC and are associated with poor pathological parameters and prognosis.
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