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Archive > Volume 29 Issue 10 > 2022,29(10):921-929. DOI:10.3872/j.issn.1007-385X.2022.10.008 Prev Next
Clinical Research
Effects of uncoupling protein 2 on prognosis and immune microenvironment of skin cutaneous melanoma
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Abstract:
Objective: To investigate the prognostic value of uncoupling protein 2 (UCP2) expression in skin cutaneous melanoma (SKCM) and its relationship with tumor infiltrating immune cells (TICs). Methods: GEPIA online dataset was used to explore the differential expression of UCP2 between SKCM and normal skin tissues, and the correlation of UCP with the prognosis of SKCM was further investigated. HPA dataset was used to analyze the UCP2 expression in single cell of normal skin. TISCH was used to analyze the expression of UCP2 in SKCM at single-cell level. TIMER was used to analyze the correlation between the expression of UCP2 and the main immune cells and their markers in the tumor microenvironment (TME) of SKCM, Primary-SKCM and Metastasis-SKCM.Results: UCP2 was highly expressed in SKCM tissues (P<0.05). Higher UCP2 expression were significantly associated with longer overall survival (OS) and disease-free survival (DFS) of SKCM patients (all P<0.05). Single cell analysis of normal skin and SKCM skin showed that there was a certain positive correlation between UCP2 expression and cellular immune cell subsets and that UCP2 was closely related to 5 immune routes (chemokines, receptors, histocompatibility complexes, immunosuppressants and immune activators) (all P<0.05). The subset analysis showed that high UCP2 expression was closely associated with the high OS rate of SKCM and metastatic SKCM patients (all P<0.05). There was a significant positive correlation between UCP2 expression and TICs in the TME of overall SKCM patients, primary SKCM patients and metastatic SKCM patients (all P<0.05), however, the correlation was relatively low in primary SKCM patients. At the same time, the expression of UCP2 was positively correlated with TME immune cell markers in the three groups of SKCM patients. Conclusion: UCP2 is highly expressed in SKCM tissues and positively correlates with TICs in SKCM, which is an important regulatory factor of TME and closely related to the prognosis of SKCM patients.
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