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Archive > Volume 29 Issue 11 > 2022,29(11):1038-1044. DOI:10.3872/j.issn.1007-385X.2022.11.015 Prev Next
Clinical Research
Expression, function and clinical significance of MELK in pancreatic cancer
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Abstract:
Objective: To investigate the expression, function and clinical significance of maternal leucine zipper kinase (MELK) in pancreatic cancer. Methods: The expression of MELK in pancreatic cancer was analyzed and the possible molecular mechanism of MELK in pancreatic cancer was predicted by bioinformatics. The clinical data of 45 patients with pancreatic cancer undergoing surgical treatment in the First Hospital of Lanzhou University were retrospectively analyzed. Immunohistochemistry was used to explore the MELK expression levels in pancreatic cancer tissues and normal para-cancerous tissues, and its relationship with clinical pathological characteristics was also analyzed. The postoperative recurrence time of patients was collected through outpatient records and telephone follow-up to explore the relationship between MELK expression and postoperative recurrence time. Results: MELK mRNA was highly expressed in pancreatic cancer tissues and correlated with the overall survival rate and postoperative recurrence time. Multivariate Cox analysis showed that the MELK gene could be used as an independent prognostic factor in patients with pancreatic cancer. Functional enrichment suggests that MELK is involved in multiple cancer-related functional pathways and is positively correlated with the pathogenic molecules of pancreatic cancer. Immunohistochemistry results showed that MELK in pancreatic cancer tissues was significantly higher than that in adjacent normal tissues. The expression of MELK in pancreatic cancer tissues was correlated with tumor size. Conclusion: The MELK gene is highly expressed in pancreatic cancer tissues and is associated with patients’prognosis. MELK plays a role in the progression of pancreatic cancer and is expected to become a potential biomarker and therapeutic target of pancreatic cancer.
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