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Archive > Volume 29 Issue 12 > 2022,29(12):1057-1066. DOI:10.3872/j.issn.1007-385X.2022.12.001 Prev Next
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NK cells within tumor immune microenvironment and immunotherapy
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Abstract:
Natural killer (NK) cells, a kind of innate lymphocyte with strong anti-tumor function, can quickly recognize and kill tumor cells. Their function is regulated by a variety of signals of activating and inhibitory receptors. However, the killing function of tumor-infiltrating NK cell is dysregulated due to the immunosuppressive tumor microenvironment, which may even promote the immune escape of tumor cells, resulting in poor clinical therapeutic effects of various immunotherapies. Up-regulated expression of inhibitory ligands on tumor cells, a large number of anti-inflammatory cytokines in the tumor microenvironment, abnormal hypoxia, low pH, and other indicators induced impaired killing function of tumor-infiltrating NK cells. In recent years, the research on tumor microenvironment and tumor infiltrating NK cells is at the forefront of tumor immunity, and many clinical research results have been achieved. Many studies have shown that tumor-infiltrating NK cells are usually characterized by up-regulation of inhibitory receptors, down-regulation of activating receptors, and abnormal metabolism. Based on this, researchers have developed many targeted therapies to restore the killing function of NK cells. In this paper, we summarize the characteristics of tumor-infiltrating NK cells and the related tumor immunotherapies based on the mechanisms of activation and inhibition of NK cell function.
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